Rationale of composition

Synergy and bioavailability: Two important aspects of a successful weight loss program

LeanGard® formula benefits from synergy of four botanical compounds: hydroxycitric acid (HCA), garcinol (both compounds extracted from rinds of Garcinia gambogia), diterpene forskolin (Coleus forskohlii root extract) and alkaloid piperine (Piper nigrum fruits extract).

The interest in HCA (Hydroxycitric Acid), extracted from the rind of the Garcinia cambogia fruit, as a supportive element in weight management dates back to the 1970s. Despite its potential, varied outcomes in clinical trials have suggested challenges related to its absorption and bioavailability within the body, particularly concerning its ability to reach and influence citrate lyase, an enzyme involved in fat production. LeanGard® aims to enhance the effectiveness of HCA by combining it with garcinol, another compound derived from the Garcinia fruit rind, known for its antioxidant, supportive properties in inflammation management, and potential in promoting overall health. Additionally, garcinol is observed to support liver function by increasing detoxification enzyme levels, such as glutathione S-transferase and quinone reductase, contributing to improved metabolism and aiding in the removal of metabolic by-products that could influence weight management efforts.

LeanGard® biological mechanism further benefits from addition of diterpene froskolin, a compound derived from roots of Coleus forskohlii plant, which uniquely regulates body composition by enhancing adenylate cyclase and cAMP cellular levels, increasing lean body mass and decreasing content of body fat. Increased lean body mass up-regulates body metabolism and helps mitigate body weight gain, as well as maintaining the accomplished weight reduction in the long-run, i.e. prevention of so-called yo-yo effect.

It has been recognized recently that diminished lean body mass slows down body metabolism and results in difficulties in maintaining an appropriate and healthy body composition and weight.

Thus, synergistic components of LeanGard® provide a sensible weight management approach to reduce body weight to acceptable levels by restoring the optimal proportions of fat to lean body mass. By maintaining or increasing lean body mass while simultaneously reducing body fat, the weight loss regimen would serve the general purpose of improving the overall health of the individual. Lean body mass can simply be described as total body weight minus fat and it is inversely correlated with morbidity and mortality rates.

LeanGard® formula has an additional mechanism to secure gastrointestinal absorption and ultimately bioavailability of all above discussed ingredients by including in its composition 5mg of 95% pure alkaloid piperine. Piperine, a pungent compound extracted from blackpepper fruits is known to assist absorption of variety of nutrients and also to improve diminished nutrient absorption which typically occurs with aging. In fact, the efficacy of many weight-loss nutriceuticals is known to be diminished in middle-aged and elderly population.

The therapeutic effects of the individual components of LeanGard® evaluated in the preclinical and human studies include a reduction in total body weight and body mass index, a reduction in body fat, an increase in lean body mass and content of body water, and a reduction in perceived appetite level while increasing energy levels. The unique combination of LeanGard® ingredients results in enhancement of the biological activity of the weight loss components and also in the antioxidant and anti-inflammatory properties of garcinol.

LeanGard® is a total formula for securing your health. LeanGard® is a combination of these patented ingredients.